ABSTRACT
We present a case of successfully treated persistent bacteremia due to Gram-positive
bacteria with daptomycin in a preterm neonate. Daptomycin was given at higher doses
(6 mg/kg/dose) and shorter intervals (every 12 hours) than those recommended for adults
with no adverse events. Peak and trough serum concentrations of daptomycin were 22.9
and 11.6 μg/mL at day 4 as well as 27.3 and 7.9 μg/mL at day 11 after initiation of
treatment, respectively.
KEYWORDS
Daptomycin - neonate - drug monitoring - enterococcal bacteremia
REFERENCES
- 1
Sauermann R, Rothenburger M, Graninger W, Joukhadar C.
Daptomycin: a review 4 years after first approval.
Pharmacology.
2008;
81
79-91
- 2
Ardura M I, Mejías A, Katz K S, Revell P, McCracken Jr G H, Sánchez P J.
Daptomycin therapy for invasive gram-positive bacterial infections in children.
Pediatr Infect Dis J.
2007;
26
1128-1132
- 3
Abdel-Rahman S M, Benziger D P, Jacobs R F, Jafri H S, Hong E F, Kearns G L.
Single-dose pharmacokinetics of daptomycin in children with suspected or proved gram-positive
infections.
Pediatr Infect Dis J.
2008;
27
330-334
- 4
Cohen-Wolkowiez M, Smith P B, Benjamin Jr D K, Fowler Jr V G, Wade K C.
Daptomycin use in infants: report of two cases with peak and trough drug concentrations.
J Perinatol.
2008;
28
233-234
- 5
Sakoulas G, Golan Y, Lamp K C, Friedrich L V, Russo R.
Daptomycin in the treatment of bacteremia.
Am J Med.
2007;
120(10 Suppl 1)
S21-S27
- 6
Mohr J F, Friedrich L V, Yankelev S, Lamp K C.
Daptomycin for the treatment of enterococcal bacteraemia: results from the Cubicin
Outcomes Registry and Experience (CORE).
Int J Antimicrob Agents.
2009;
33
543-548
- 7
Dvorchik B, Arbeit R D, Chung J, Liu S, Knebel W, Kastrissios H.
Population pharmacokinetics of daptomycin.
Antimicrob Agents Chemother.
2004;
48
2799-2807
- 8
Benvenuto M, Benziger D P, Yankelev S, Vigliani G.
Pharmacokinetics and tolerability of daptomycin at doses up to 12 milligrams per kilogram
of body weight once daily in healthy volunteers.
Antimicrob Agents Chemother.
2006;
50
3245-3249
- 9
Castanheira M, Jones R N, Sader H S.
Update of the in vitro activity of daptomycin tested against 6710 gram-positive cocci
isolated in North America (2006).
Diagn Microbiol Infect Dis.
2008;
61
235-239
- 10
Malli E, Spiliopoulou I, Kolonitsiou F et al..
In vitro activity of daptomycin against gram-positive cocci: the first multicentre
study in Greece.
Int J Antimicrob Agents.
2008;
32
525-528
Emmanuel RoilidesM.D. Ph.D.
Associate Professor, 3rd Department of Pediatrics, Aristotle University
Hippokration General Hospital, Kostantinoupoleos 49, 54642, Thessaloniki, Greece
Email: roilides@med.auth.gr
